Suboxone: Side effects, dosage, use for dependence, and more

Data sources include Micromedex (updated 1 Apr 2024), Cerner Multum™ (updated 2 Apr 2024), ASHP (updated 10 Apr 2024) and others. Other drugs may interact with buprenorphine and naloxone, including prescription and over-the-counter medicines, vitamins, and herbal products. For more information on Suboxone doses, refer to the “Dosages of Suboxone” section above. This includes information about recommended dosages, including the lowest dose and highest dose typically prescribed. Or, you can view the drug’s full prescribing information.

If they’re more severe or don’t go away, talk with your doctor or pharmacist. Ideally patients should be seen at reasonable intervals (e.g., at least weekly during the first month of treatment) based upon the individual circumstances of the patient. Medication should be prescribed in consideration of the frequency of visits. Provision of multiple refills is not advised early in treatment or without appropriate patient follow-up visits. Periodic assessment is necessary to determine compliance with the dosing regimen, effectiveness of the treatment plan, and overall patient progress.

A 2016 clinical study found that Suboxone was more effective for reducing opioid use than naltrexone over 12 weeks. Naltrexone is classified as an opioid antagonist, similar to the naloxone contained in Suboxone. Suboxone is available as an oral film that can be used under your tongue (sublingual) or between your gums and your cheek (buccal). It’s also available as a brand-name version called Diskets. Suboxone comes as an oral film that can be used under your tongue (sublingual) or between your gums and your cheek (buccal).

  1. Vivitrol usually costs much more than brand-name or generic Suboxone.
  2. Suboxone and sublingual buprenorphine are very similar drugs and cause similar common and serious side effects.
  3. You should receive regular dental checkups while using Suboxone.
  4. You may wonder how Suboxone compares to other drugs used to treat opioid dependence.
  5. The smallest tablets are usually 2 mg and the largest is usually 12 mg.

Suboxone helps you reduce a craving for the pleasure rush of opioids. It also eases withdrawal symptoms that you have when you stop taking opioids. Buprenorphine has better absorption when given sublingually compared to orally. The government has created special rules for how schedule III drugs can be prescribed by a doctor and dispensed by a pharmacist. Taking codeine with Suboxone can increase the risk of side effects such as decreased breathing. Suboxone may also make codeine less effective for treating pain.

Is Suboxone Treatment Right for You?

Methadone is also FDA-approved to treat moderate-to-severe pain. This process may go on for additional days until your withdrawal symptoms are well-controlled and the correct dose of Suboxone for you has been determined. You’ll then continue on this dose once per day as your maintenance dosage. Once on your maintenance dosage, you can dissolve Suboxone under your tongue or between your cheek and gums. Do not take SUBOXONE Sublingual Film with certain medicines.

When Suboxone is dispensed, an expiration date is added to the label on the bottle. This date is typically one year from the date the medication was dispensed. You can take Suboxone on an empty stomach or after a meal, since it’s absorbed in your mouth and not your stomach. However, you should not consume food or drink anything while the film is in your mouth. It’s important to practice good oral hygiene while you’re taking Suboxone.

Buprenorphine Guides

Naltrexone usually costs less than brand-name or generic Suboxone. The actual amount you pay will depend on your insurance. Vivitrol usually costs much more than brand-name or generic Suboxone. Zubsolv usually costs less than brand-name or generic Suboxone. However, the actual amount you pay will depend on your insurance.

If it’s mixed with food or drinks while it’s already in the process of dissolving, the medication will get swallowed and it won’t produce the desired effects. It’s best to drink water or some other drink before using tablets or strips because the water will provide more moisture and allow the medication to dissolve quicker. You’ll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Links to other websites are provided for your convenience and general informational purposes only. The terms of use and privacy statement on the website will not apply to other websites.

For maintenance, SUBOXONE sublingual film may be administered buccally or sublingually. ​Patients dependent on heroin or short-acting opioid products may be inducted with either SUBOXONE sublingual film or with sublingual buprenorphine monotherapy. Someday you may face a sudden, short-term health problem such as surgery or an injury. If an opioid is prescribed, let your healthcare team know if you had any trouble tapering off opioids in the past. If you’ve successfully tapered off opioid medicine in the past, taking opioids for a brief time — with guidance from your healthcare professional — may be OK.

Suboxone is sometimes prescribed off-label to help manage opioid withdrawal symptoms as part of a detoxification program. Suboxone should only be used with short-acting opioids. This is because use with long-acting opioids will cause increased withdrawal symptoms. Short-acting opioids include heroin, codeine, morphine, and oxycodone (Oxycontin, Roxicodone). However, using the film could cause withdrawal symptoms if it’s taken while you still have other opioids in your system.

Suboxone vs. Naltrexone

Place one film on the inside of the right or left cheek. If an additional film is necessary to achieve the prescribed dose, place an additional film on the inside of the opposite cheek. The film must be kept on the inside of the cheek until the film is completely dissolved. If a third film is necessary to achieve the prescribed dose, place it on the inside of the right or left cheek after the first two films have dissolved. Suboxone sublingual tablets should be placed under the tongue until they dissolve. Before taking a Suboxone sublingual film, drink water to moisten your mouth.

In addition, buprenorphine is also administered at SAMHSA-certified opioid treatment programs (OTPs). Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medicine in a place where others cannot get to it.

Reports of Suboxone withdrawal showed that most symptoms typically peak by the third and fourth days of withdrawal, and could last up to 2 weeks. However, this withdrawal is less likely to occur when you use the Suboxone film. This is because the film releases less naloxone into your body than an injection does. Buprenorphine, one of the drugs contained in Suboxone, is also used for pain. However, studies of how effective it is for this purpose have had mixed results.

If you feel the need to manage withdrawal symptoms, talk to your healthcare team right away. If you’ve taken opioid medicine for more than 7 to 10 days, it’s likely you need to stop soon — and stop slowly — are toads dangerous to humans to keep from having symptoms of withdrawal. Keep SUBOXONE Sublingual Film in a secure place out of sight and reach of children, and in a location not accessible by others, including visitors to the home.

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